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We compared the frequency of malignancies in 207 multiple sclerosis patients(mean age 35.75 years,SD 10.60)who took 2.0 mg/kg azathioprine daily(mean duration 4.16 years;SD 2.38)and in 247 nontreated patients(mean age 35.44 years,SD 11.94).Five malignancies were diagnosed in the azathioprine group compared with seven in the control group.The age- adjusted occurrence rate was 3.62/1,000 person-years(95%CI,1.17 to 8.43)in the treated and 4.24/1,000 person-years(95%CI,1.70 to 8.73)in the nontreated group;the age-adjusted relative risk of developing a tumor was 0.85. |
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